Steffen Ventz

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Submitted and Invited Revisions

  • Steffen Ventz and Lorenzo Trippa (2021):
    Bayesian Multi-Arm De-Intensification Designs.
    Bayesian Analyses (invited revision).

  • Steffen Ventz, Sean Khozin, Bill Louv, Jacob Sands, Rifaquat Rahman, Leah Comment, Lorenzo Trippa and Brian M. Alexander (2021):
    Design and Evaluation of Hybrid Controlled Trials Leveraging External Data and Randomization.
    Nature Communications (invited revision).

  • Julie C. Lauffenburger, Niteesh K. Choudhry, Massimiliano Russo, Robert J. Glynn, Steffen Ventz and Lorenzo Trippa. (2021):
    Leveraging adaptive randomized trials for the evaluation of interventions in health services and implementation research: potential advantages and practical considerations.
    (submitted).

  • Marta Bonsaglio, Sandra Fortini, Steffen Ventz and Lorenzo Trippa (2021):
    Approximating operating characteristics of Bayesian uncertainty directed trial designs.
    (submitted)

Refereed Journal Publications

  • Steffen Ventz, Rahul Mazumder, and Lorenzo Trippa (2021):
    Integration of survival data from multiple studies.
    Biometrics (in press).
    DOI: 10.1111/biom.13517

  • Steffen Ventz, Leah Comment, Bill Louv, Patrick Y. Wen, Brian M. Alexander, and Lorenzo Trippa (2021):
    The use of external control data for predictions and interim analyses in clinical studies.
    Neuro-Oncology (in press).
    DOI: 10.1093/neuonc/noab141

  • Steffen Ventz, Sergio Bacallado, Rifaquat Rahman, Sara Tolaney, Jonathan D. Shoenfeld, Brian M. Alexander and Lorenzo Trippa (2021):
    The Effects of Releasing Early Results from Ongoing Clinical Trials.
    Nature Communications 12(801): 1-7.
    DOI: 10.1038/s41467-021-21116-4

  • Massimiliano Russo, Steffen Ventz and Lorenzo Tripp (2021):
    Inference in response-adaptive clinical trials when the enrolled population varies over time.
    Biometrics (in press).
    DOI: 10.1111/biom.13582

  • Rifaquat Rahman, Steffen Ventz, Jon McDunn, Bill Louv, Irmarie Reyes-Rivera, Mei-Yin Chen Polley, Fahar Merchant, Lauren E. Abrey, Joshua Allen, Laura K. Aguilar, Estuardo Aguilar, Cordova, David Arons, Kirk Tanner, Stephen Bagley, Mustafa Khasraw, Timothy Cloughesy, Patrick Y. Wen, Brian M. Alexander, Lorenzo Trippa (2021):
    Leveraging External Data for Externally Controlled Trial Designs in Oncology.
    The Lancet Oncology 22(10): e456--e465.
    DOI: 10.1016/S1470-2045(21)00488-5

  • Geoffrey Fell, Robert Redd, Alyssa M. Vanderbeek, Rifaquat Rahman, Andrea Arfe, Brian M. Alexander, Steffen Ventz * (* Co-last author) and Lorenzo Trippa * (2021):
    Kmdata: A curated database of recapitulated individual patient level data from 160 oncology clinical trials published between 2014 and 2016.
    DATABASE Vol 2021: article ID baab037 .
    DOI: 10.1093/database/baab037

  • Shervin Tabrizi, Lorenzo Trippa, Daniel Cagney, Ayal A. Aizer, Shyam Tanguturi, Steffen Ventz, Geoffrey Fell, Jennifer R. Bellon, Harvey Mamon, Paul L. Nguyen, Anthony V. D’Amico, Daphne Haas-Kogan, Brian M. Alexander, and Rifaquat Rahman (2021):
    Interpreting randomized trials in oncology with incorporation of covid-19 risk associated with cancer therapy.
    Journal of the American Medical Association - Network 4(3): e213304.
    DOI: 10.1001/jamanetworkopen.2021.3304

  • Nadine Tung, Mark E. Robson, Steffen Ventz, Cesar Santa-Maria, Rita Nanda, Paul Kelly Marcom, Payal D. Shah, Tarah J. Ballinger, Eddy Yang, Shaveta Vinayak, Michelle Melisko, Adam Brufsky, Michelle DeMeo, Colby Jenkins, Susan Domchek, Alan D’Andrea, Nancy Lin, Melissa Hughes, Nick Wagle, Gerburg Wulf, Ian E. Krop, Antonio C. Wolff, Eric P. Winer and Judy E. Garber. (2020):
    Tbcrc 048: A phase ii study of olaparib monotherapy in metastatic breast cancer patients with germline or somatic mutations in homologous recombination (hr)-pathway genes (olaparib expanded).
    Journal of Clinical Oncology 38(36): 4274-4282..
    DOI: 10.1200/JCO.20.02151

  • Shervin Tabrizi, Lorenzo Trippa, Daniel Cagney, Shyam Tanguturi, Steffen Ventz, Geoffrey Fell, Patrick Y. Wen, Brian M. Alexander, Rifaquat Rahman (2020):
    A Quantitative Framework for Modeling COVID-19 Risk During Adjuvant Therapy Using Published Randomized Trials of Glioblastoma in the Elderly.
    Neuro-Oncology 22(7):918–927 .
    DOI: 10.1093/neuonc/noaa111

  • Andrea Arf, Steffen Ventz and Lorenzo Trippa (2020):
    Shared and usable data from phase i oncology trials: an unmet need.
    Journal of the American Medical Association - Oncology 6(7):980-981 .
    DOI: 10.1001/jamaoncol.2020.0144

  • Steffen Ventz, Lorenzo Trippa, and Jonathan D. Schoenfeld (2019):
    Lessons Learned from De-escalation trials in favorable risk HPV-associated Squamous Cell Head and Neck Cancer – A Perspective on future trial designs.
    Clinical Cancer Research 25(24): 7281-7286.
    DOI: 10.1158/1078-0432.CCR-19-0945

  • Steffen Ventz, Albert Lai, Timothy F. Cloughesy, Patrick Y. Wen, Lorenzo Trippa, and Brian M. Alexander (2019):
    Design and evaluation of an external control arm using prior clinical trials and real-world data.
    Clinical Cancer Research 25(16):4993–5001 .
    DOI: 10.1158/1078-0432.CCR-19-0820

  • Steffen Ventz, Matteo Cellamare, Sergio Bacallado and Lorenzo Trippa (2019):
    Bayesian Uncertainty Directed Trial Designs.
    Journal of the American Statistical Association 114(527):962-974.
    DOI: 10.1080/01621459.2018.1497497

  • Steffen Ventz, Ilaria Dominicano, Matteo Cellamare, Raymond H. Mak, and Lorenzo Trippa (2019):
    Bayesian Uncertainty-Directed Dose-Finding Designs.
    Journal of the Royal Statistical Society - C 68(5):1393-1410.
    DOI: 10.1111/rssc.12355

  • Alyssa M. Vanderbeek, Steffen Ventz (*co-first author), Rifaquat Rahman, Geoffrey Fell, Lorenzo Trippa, and Brian M. Alexander (2019):
    To randomize, or not to randomize, that is the question: a meta-analytic methodology for determining the context-specific value of randomization.
    Neuro-Oncology 21(10):1239-1249.
    DOI: 10.1093/neuonc/noz097

  • Rifaquat Rahman, Steffen Ventz (*co-first author), Geoffrey Fell, Alyssa M. Vanderbeek, Lorenzo Trippa, and Brian M. Alexander (2019):
    Divining responder populations from survival data.
    Annals of Oncology30(6): 1005–1013,
    DOI: 10.1093/annonc/mdz087

  • Rifaquat Rahman, Geoffrey Fell, Steffen Ventz, Andrea Arf, Alyssa M. Vanderbeek, Lorenzo Trippa, and Brian M. Alexander (2019):
    Deviation from the proportional hazards assumption in randomized phase 3 clinical trials in oncology: Prevalence, associated factors and implications.
    Clinical Cancer Research 25(21): 6339-6345.
    DOI: 10.1158/1078-0432.CCR-18-3999

  • Steffen Ventz, Brian M. Alexander and Lorenzo Trippa (2018):
    Bayesian Adaptive Randomization in Dose-Finding Trials.
    Journal of the American Medical Association - Network 1(8):e186075.
    DOI: 10.1001/jamanetworkopen.2018.6075

  • Alyssa M. Vanderbeek, Rifaquat Rahman, Geoffrey Fell, Steffen Ventz, Tianqi Chen, Robert Redd, Giovanni Parmigiani, Timothy F. Cloughesy, Patrick Y. Wen, Lorenzo Trippa, Brian M. Alexander (2018):
    The clinical trials landscape for glioblastoma: is it adequate to develop new treatments?
    Neuro-Oncology 20(8): 1034–1043,
    DOI: 10.1093/neuonc/noy027

  • Steffen Ventz, Matteo Cellamare, Giovanni Parmigiani and Lorenzo Trippa (2018):
    Adding Experimental Arms into an Ongoing Multi-Arm Trial.
    Biostatistics 19(2):199–215,
    DOI: 10.1093/biostatistics/kxx030

  • Emma Schwager, Himel Himmel, Steffen Ventz and Curtis Huttenhower (2017):
    A Bayesian Method for Detecting Pairwise Associations in Compositional Data.
    PLOS Computational Biology PLoS Comput Biol 13(11): e1005852,
    DOI: 10.1371/journal.pcbi.1005852

  • Steffen Ventz, Brian M. Alexander, Giovanni Parmigiani, Richard D. Gelber and Lorenzo Trippa (2017):
    Designing Clinical Trials that Accept New Arms: An Example in Metastatic Breast Cancer.
    Journal of Clinical Oncology 35(27): 3160-3168.
    DOI: 10.1200/JCO.2016.70.1169

  • Steffen Ventz, William T. Berry, Giovanni Parmigiani and Lorenzo Trippa (2017):
    Bayesian Response-Adaptive Designs for Basket Trials.
    Biometrics 73(3):905-915,
    DOI: 10.1111/biom.12668

  • Steffen Ventz, Giovanni Parmigiani and Lorenzo Trippa (2017):
    Combining Bayesian Experimental Designs and Frequentist Data Analyses: Motivations and Examples.
    Applied Stochastic Models in Business and Industry 33(3):302-313,
    DOI: 0.1002/asmb.2249

  • Matteo Cellamare*, Steffen Ventz* (*co-first author), Elisa Baudin, Carol D. Mitnick and Lorenzo Trippa (2016):
    A Bayesian Response-Adaptive Trial in Tuberculosis: The endTB trial.
    Clinical Trials 14(1):17-28,
    DOI: 10.1177/1740774516665090

  • Matteo Cellamare*, Melisa Milstein*, Steffen Ventz* (*co-first author), Elisa Baudin, Lorenzo Trippa, and Carol D. Mitnick (2016):
    Bayesian Adaptive Randomization to Identify New Regimens for Multidrug-Resistant Tuberculosis: The endTB Trial.
    International Journal of Tuberculosis and Lung Disease 20(12): S8-S12,
    DOI: 10.5588/ijtld.16.0066

  • Steffen Ventz and Lorenzo Trippa (2015):
    Bayesian Designs and the Control of Frequentist Characteristics:A Practical Solution.
    Biometrics 71 (1): 218-226,
    DOI: 10.1111/biom.12226

  • Elodie Hatchi, Konstantina Skourti-Stathaki, Steffen Ventz, Luca Pinello, Angela Yen, Kinga Kamieniarz-Gdula, Stoil Dimitrov, Shailja Pathania, Kris- tine M. McKinney, Matthew L. Eaton M. Kellis, Giovanni Parmigiani, N.J. Proudfoof, D.M. Livingston and S.J. Hill (2015):
    BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair.
    Molecular Cell 57(4): 636-647,
    DOI: 10.1016/j.molcel.2015.01.011