DFCI Knowledge Systems Group


The Knowledge Systems Group is an applied genomics software and data sciences group, focused on enabling cancer genomics research and precision cancer medicine at Dana-Farber Cancer Institute.

Enabling Precision Cancer Medicine

We are currently focused on four areas of research and development:

First, we collaborate with MSKCC on the continued development of the cBioPortal for Cancer Genomics, an open source platform for mining cancer genomics data sets.

Second, we are actively collaborating with translational researchers and clinicians to mine genomic data generated by Dana-Farber's enterprise sequencing project --- now one of the largest databases of genomic data linked to detailed clinical data.

Third, we are building new genomic tools for clinicians, including a new clinical trial matching platforms for algorithmically matching genomic profiles to open clinical trials.

And, lastly, we are helping to build new cloud-based platforms for securely sharing genomic data across multiple cancer centers, while preserving patient confidentiality.

Open Source, Open Data

We have a strong focus on open-source software development, and believe that open science and open data can result in the best possible science and the best possible patient care.

Our long-term goal is to work with multiple cancer centers to build one of the most comprehensive knowledgebases of genomic data integrated with detailed clinical data, and use this knowledgebase to provide the best possible care for all cancer patients.

An interdisciplinary group of Computational Biologists and Bioinformatics Engineers

We are an interdisciplinary group of computational biologists, bioinformatics engineers, and software developers. The Knowledge Systems Group is also part of the new cBio Center, headed by Chris Sander, providing us with multiple avenues of collaboration within Dana-Farber and across Harvard Medical School.

Latest News

  • DFCI to build new Cancer Immunologic Data Commons (CIDC)

    February 14, 2018

    Dana-Farber Cancer Institute (PIs: X. Shirley Liu and Ethan Cerami) was recently selected to build the new NCI Cancer Immuno-Data Commons (CIDC). This is a 5-year multi-institutional effort, and we are excited to get started!

    Read about the award here. And check out our new open positions.

  • cBioPortal awarded NCI Grant

    Sep 11, 2017

    We are happy to report that the cBioPortal for Cancer Genomics was recently awarded a multi-institutional NCI award.