Dana-Farber Cancer Institute
Harvard School of Public Health
I develop new computational approaches to investigate different epigenetic factors that regulate the chromatin structure and the gene expression integrating NGS for instance: ChIP-seq, RNA-seq, Bisulfite-seq.
I have experience analizing data from recent single cell assays for gene expression, such as single cell RNA-seq and multiplexed qPCR.
I am embracing the new revolution in functional genomics made possible by the novel genome editing approaches such as CRISPR/Cas9 and TALEN developing new tools to undestand and visualize the outcome of these wet lab experiments.
I have had the good fortune to be part of the "omics" revolution and the opportunity to work on many computationally-challenging problems on the role of chromatin structure in gene regulation.Over the course of my academic career, my major focus has been to unravel the role of epigenetic mechanisms that influence gene expression, including nucleosome positioning, DNA methylation and histone modifications. My research has emphasized the critical interplay between epigenetic mechanisms and linear DNA sequences: in fact I showed that epigenetic patterns can be characterized and predicted from DNA sequences.
I aim to become an independent investigator with a research program that uses computational approaches to systematically analyze the sources of variation that affect gene regulation: epigenetic variation, genetic variation and (single-cell) gene expression variability.
Tools and software for Computational Biology
Get in touch with me