The main research interests of our lab are to develop systems biology approaches for characterizing cell states and understanding the regulatory circuitry. To this end, we take advantage of the existing large amount of omic-level datasets and develop computational methods to analyze and integrate various genomic data types, with the focus on chromatin dynamics and single-cell analysis. In collaboration with experimental biologists and clinical scientists, we have applied these computational approaches to study stem cell and cancer biology. We are excited to be involved in the International Human Cell Atlas Initiative.

Postdoc Position Available

We are currently recruiting a postdoc to work in the field of either (1) gene regulation or (2) single-cell analysis. The candidate will develop novel computational methods for analyzing and integrating genomic, transcriptomic, and epigenomic data types often at the single-cell resolution. The long-term goal is to comprehensively characterize the heterogeneity and dynamics of cellular states and to investigate the mechanism underlying cell-state maintenance and transitions. The candidate will have the opportunity to closely interact with both computational biologists at Harvard School of Public Health as well as experimental biologists and clinical investigators at Dana-Farber and other Harvard affiliated hospitals.

The successful applicant should hold a doctoral degree in a quantitative field and be enthusiastic with solving biological problems. Candidate holding a degree in biological science will also be considered if they have demonstrated experience in computational or statistical work. Strong programming (in Matlab, R, C/C++, or Python) and communication skills are required. Previous experience in analysis, interpretation, and integration of genomic, transcriptomic or epigenomic data is necessary.

Interested applicants please send CV and at least two recommendation letters.

Our Coordinate

Room 1060, Longwood Center
Street Address: 360 Longwood Ave, Boston. MA 02215.
Click here for a map of the area.

Mailing Address

Dept of Biostatistics and Computational Biology, LC1060, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215

Email: gcyuan at jimmy dot harvard dot edu