Supplementary Table 3. Transcripts showing differential expression in GRN+ FTLD-U compared to normal controls; 6 FTLD-U cases with progranulin gene abnormalities (GRN+ FTLD-U) were compared to 8 normal controls on Affymetrix U133A microarrays. A statistical cutoff of p<0.001 was used to identify genes with differential expression  which were then ranked based on fold change (FC  disease/normal). All genes with fold change >2  identified by GeneSymbol and name  are shown for frontal cortex samples.

Table 2: Comparison of the effect of PI 3-kinase inhibition on gene expression in U937 and T98G cells; Proliferating U937 and T98G cells were treated with LY294002 for 4 hours and gene expression was quantitated by RT-PCR. Data are expressed as average fold changes from two independent experiments.

Table 1: Gene expression changes after 2 and 4 hours of PI 3-kinase inhibition

Table W2. The set of 73 (top-ranked) Genes in the Outcome Signature.

Table W1. Selection of Genes from Microarrays Which Are Specifically Upregulated at P7 and Downregulated at P14. Ratios between signal at P7 and signal at P2 and P14/P7 are indicated. Numbers are averages from duplicate experiments. Only genes modulated more than 2.5-fold are shown.

Table 1. Differentially Expressed Genes in Normal Ovaries of p53Ala135Val/wt Mice. (B) Altered expression of p53 mutation-related genes

Table 3. Differentially Expressed Genes (>2.0-Fold  P < 0.05) only in p53Ala135Val/wt Tumor (T+/-); Genes that were altered only in p53Ala135Val/wt tumors as compared with p53wt/wt tumors and only in p53val135/wt normal ovary as compared with p53wt/wt normal ovary

Table 1. Differentially Expressed Genes in Normal Ovaries of p53Ala135Val/wt Mice. (A) Differentially expressed genes identified by microarray analysis in normal ovaries of p53Ala135Val/wt mice with normal ovaries of p53wt/wt mice as control (12 unknown sequences were not listed)

Table 2. Differentially Expressed Genes Identified by Microarray Analysis in the Comparison of Tumor to Normal p53wt/wt and p53Ala135Val/wt Mice and in Human Ovarian Tumors