Table 2a. Genes differentially upregulated in GEP cluster #4 AML cases with silenced CEBPA compared to GEP cluster #4 cases with CEBPA mutation.

Table 2b. Genes differentially downregulated in GEP cluster #4 AML cases with silenced CEBPA compared to GEP cluster #4 cases with CEBPA mutation.

Supplementary Table 1.   Upregulated genes in WT testis exposed to E2 (> 2fold change). Expt  compared mRNA expression profiles in testes of E18.5 embryos exposed to either vehicle or a supraphysiological dose of E2 (a single ip injection of 6 mg E2 at 13.5 dpc).  Expt measures the effect of fetal exposure to estrogen E2 on testicular gene expression to examine the failure of testes to descend into the scrotum.  In utero exposure to estrogens  such as 17 -estradiol (E2) or the synthetic estrogen diethylstilbestrol (DES)  down-regulates insulin-like 3 (Insl3) expression in embryonic Leydig cells  which in turn results in cryptorchidism in mice

TABLE 1. Down regulated genes in WT testis exposed to E2  (>2 fold change) in WT testis exposed to estrogen E2 by  comparing mRNA expression profiles in testes of E18.5 embryos exposed to either vehicle or a supraphysiological dose of E2 (a single ip injection of 6 mg E2 at 13.5 dpc) . Expt measures the effect of fetal exposure to estrogen E2 on testicular gene expression to examine the failure of testes to descend into the scrotum.  In utero exposure to estrogens  such as 17 -estradiol (E2) or the synthetic estrogen diethylstilbestrol (DES)  down-regulates insulin-like 3 (Insl3) expression in embryonic Leydig cells  which in turn results in cryptorchidism in mice

Supplementary Table 2. Downregulated genes in ER alpha KO testis exposed to E2 (> 2fold change).  Expt measures the effect of fetal exposure to estrogen E2 on testicular gene expression to examine the failure of testes to descend into the scrotum.  In utero exposure to estrogens  such as 17 -estradiol (E2) or the synthetic estrogen diethylstilbestrol (DES)  down-regulates insulin-like 3 (Insl3) expression in embryonic Leydig cells  which in turn results in cryptorchidism in mice