Paul Catalano

Associate Chair/Senior Lecturer
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Research

The main line of my methodologic statistical research involves the design and analysis of studies involving mixtures of discrete and continuous outcomes, with a focus on dose-response modeling and quantitative risk assessment. Toxicologic and other early evaluation studies in animals are a specific application area, but problems related to multiple outcomes arise in a variety of research contexts.

One important application of such methods is the determination of overall risk from an exposure to an agent (drug, chemical, etc.) when the outcomes are naturally multivariate in nature. Although assessing probabilistic risk is usually straightforward, with a single outcome, in the multivariate setting the situation is often more complex because outcomes may be observed simultaneously or in a hierarchical fashion. The statistical analysis must carefully account for these features of the response profile.

My collaborative research in cancer involves statistical support on the design, monitoring and analysis of clinical trials in gastrointestinal malignancies, quality of life and laboratory/translational science study design and analysis in gatrointestinal malignancies and quality of care/outcomes research in lung cancer and colorectal cancer.

 

Biography

Dr. Catalano received his ScD in biostatistics from Harvard School of Public Health (HSPH) in 1991. He then completed a two year postdoctoral fellowship at HSPH and DFCI, joined the faculty in 1993, and became associate chair of the Department in 2001 and senior lecturer in 2005. His collaborative work is primarily in cancer clinical trials with the Eastern Cooperative Oncology Group, in outcomes and quality of care research in the CanCORS Consortium and in investigating the health effects of air pollution. His methodological research is in multiple outcomes modeling and quantitative risk assessment.

 

Recent Publications

Cagney DN, Martin AM, Catalano PJ, Redig AJ, Lin NU, Lee EQ, Wen PY, Dunn IF,
Bi WL, Weiss SE, Haas-Kogan DA, Alexander BM, Aizer AA. Incidence and prognosis of patients with brain metastases at diagnosis of systemic malignancy: A population-based study. Neuro Oncol. 2017 Apr 24.

 

Martin AM, Cagney DN, Catalano PJ, Warren LE, Bellon JR, Punglia RS, Claus EB,
Lee EQ, Wen PY, Haas-Kogan DA, Alexander BM, Lin NU, Aizer AA. Brain Metastases in Newly Diagnosed Breast Cancer: A Population-Based Study. JAMA Oncol. 2017 Mar 16.

 

Zhang H, Barysauskas C, Rickerson E, Catalano P, Jacobson J, Dalby C, Lindvall
C, Selvaggi K. The Intensive Palliative Care Unit: Changing Outcomes for
Hospitalized Cancer Patients in an Academic Medical Center. J Palliat Med. 2017
Mar;20(3):285-289.

 

Cho LP, Manuel M, Catalano P, Lee L, Damato AL, Cormack RA, Buzurovic I,
Bhagwat M, O'Farrell D, Devlin PM, Viswanathan AN. Outcomes with volume-based dose specification in CT-planned high-dose-rate brachytherapy for stage I-II cervical carcinoma: A 10-year institutional experience. Gynecol Oncol. 2016
Dec;143(3):545-551.

 

Margalit DN, Rawal B, Catalano PJ, Haddad RI, Goguen LA, Annino DJ, Limaye SA, Lorch JH, Lavigne AW, Schoenfeld JD, Sher DJ, Tishler RB. Patterns of failure

after reirradiation with intensity-modulated radiation therapy and the competing
risk of out-of-field recurrences. Oral Oncol. 2016 Oct;61:19-26.

 

Barysauskas CM, Dalby CK, Catalano PJ, Jacobson JO. An Assessment of the
Quality Oncology Practice Initiative: Lessons Learned From a Detailed Assessment of a Well-Established Profession-Based Performance Measurement Program. J Healthc Qual. 2016 Sep 13.

 

Warren LE, Ligibel JA, Chen YH, Truong L, Catalano PJ, Bellon JR. Body Mass
Index and Locoregional Recurrence in Women with Early-Stage Breast Cancer. Ann Surg Oncol. 2016 Nov;23(12):3870-3879.

 

Shyn PB, Bird JR, Koch RM, Tatli S, Levesque VM, Catalano PJ, Silverman SG.
Hepatic Microwave Ablation Zone Size: Correlation with Total Energy, Net Energy,
and Manufacturer-Provided Chart Predictions. J Vasc Interv Radiol. 2016
Sep;27(9):1389-96.

 

Manuel MM, Cho LP, Catalano PJ, Damato AL, Miyamoto DT, Tempany CM, Schmidt EJ, Viswanathan AN. Outcomes with image-based interstitial brachytherapy for vaginal cancer. Radiother Oncol. 2016 Sep;120(3):486-492.

 

Lee LJ, Howitt B, Catalano P, Tanaka C, Murphy R, Cimbak N, DeMaria R, Bu P,
Crum C, Horowitz N, Matulonis U, Viswanathan AN. Prognostic importance of human papillomavirus (HPV) and p16 positivity in squamous cell carcinoma of the vulva treated with radiotherapy. Gynecol Oncol. 2016 Aug;142(2):293-8.

 

Related Links

Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium - The Cancer Care Outcomes Research and Surveillance (CanCORS) Consortium is an NCI-funded study that is a network of sites around the country that are conducting a population-based study of access to and outcomes from cancer care, with special focus on ethnic subgroups and subgroups defined by age.

 

Recent Abstracts:

 

Eastern Cooperative Oncology Group - The Eastern Cooperative Oncology Group (ECOG) is one of the largest clinical cancer research organizations in the United States, and conducts clinical trials in all types of adult cancers.

 

Keywords

dose-response modeling