Clifford Meyer

Research Scientist
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Research

Cliff is developing methods to analyze and interpret genome-wide DNA microarray assays of transcription and protein-DNA interactions. His approach is to integrate physical and chemical insights with statistical models of DNA hybridization in order to distinguish biologically relevant signal from technical artifact. He is also working on mathematical models of transcriptional behavior that integrate microarray data with DNA sequence data.

 

Biography

 

PhD in Chemical Engineering, Princeton University

 

Recent Publications


Liu Y, Chen S, Wang S, Soares F, Fischer M, Meng F, Du Z, Lin C, Meyer C,
DeCaprio JA, Brown M, Liu XS, He HH. Transcriptional landscape of the human cell cycle. Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3473-3478.

 

Mei S, Qin Q, Wu Q, Sun H, Zheng R, Zang C, Zhu M, Wu J, Shi X, Taing L, Liu
T, Brown M, Meyer CA, Liu XS. Cistrome Data Browser: a data portal for ChIP-Seq
and chromatin accessibility data in human and mouse. Nucleic Acids Res. 2017 Jan 4;45(D1):D658-D662.

 

Qin Q, Mei S, Wu Q, Sun H, Li L, Taing L, Chen S, Li F, Liu T, Zang C, Xu H,
Chen Y, Meyer CA, Zhang Y, Brown M, Long HW, Liu XS. ChiLin: a comprehensive
ChIP-seq and DNase-seq quality control and analysis pipeline. BMC Bioinformatics. 2016 Oct 3;17(1):404.

 

Wang S, Zang C, Xiao T, Fan J, Mei S, Qin Q, Wu Q, Li X, Xu K, He HH, Brown M,
Meyer CA, Liu XS. Modeling cis-regulation with a compendium of genome-wide
histone H3K27ac profiles. Genome Res. 2016 Oct;26(10):1417-1429.

 

Zang C, Wang T, Deng K, Li B, Hu S, Qin Q, Xiao T, Zhang S, Meyer CA, He HH,
Brown M, Liu JS, Xie Y, Liu XS. High-dimensional genomic data bias correction and data integration using MANCIE. Nat Commun. 2016 Apr 13;7:11305.

 

Shu S, Lin CY, He HH, Witwicki RM, Tabassum DP, Roberts JM, Janiszewska M, Huh SJ, Liang Y, Ryan J, Doherty E, Mohammed H, Guo H, Stover DG, Ekram MB, Peluffo G, Brown J, D'Santos C, Krop IE, Dillon D, McKeown M, Ott C, Qi J, Ni M, Rao PK, Duarte M, Wu SY, Chiang CM, Anders L, Young RA, Winer EP, Letai A, Barry WT, Carroll JS, Long HW, Brown M, Liu XS, Meyer CA, Bradner JE, Polyak K. Response and resistance to BET bromodomain inhibitors in triple-negative breast cancer. Nature. 2016 Jan 21;529(7586):413-7.

 

Xu H, Xiao T, Chen CH, Li W, Meyer CA, Wu Q, Wu D, Cong L, Zhang F, Liu JS,
Brown M, Liu XS. Sequence determinants of improved CRISPR sgRNA design. Genome Res. 2015 Aug;25(8):1147-57.

 

Li N, Fassl A, Chick J, Inuzuka H, Li X, Mansour MR, Liu L, Wang H, King B,
Shaik S, Gutierrez A, Ordureau A, Otto T, Kreslavsky T, Baitsch L, Bury L, Meyer
CA, Ke N, Mulry KA, Kluk MJ, Roy M, Kim S, Zhang X, Geng Y, Zagozdzon A,
Jenkinson S, Gale RE, Linch DC, Zhao JJ, Mullighan CG, Harper JW, Aster JC,
Aifantis I, von Boehmer H, Gygi SP, Wei W, Look AT, Sicinski P. Cyclin C is a
haploinsufficient tumour suppressor. Nat Cell Biol. 2014 Nov;16(11):1080-91.

 

Meyer CA, Liu XS. Identifying and mitigating bias in next-generation
sequencing methods for chromatin biology. Nat Rev Genet. 2014 Nov;15(11):709-21.

 

Zheng X, Zhao Q, Wu HJ, Li W, Wang H, Meyer CA, Qin QA, Xu H, Zang C, Jiang
P, Li F, Hou Y, He J, Wang J, Wang J, Zhang P, Zhang Y, Liu XS. MethylPurify:
tumor purity deconvolution and differential methylation detection from single
tumor DNA methylomes. Genome Biol. 2014 Aug 7;15(8):419.

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