Emanuele Mazzola


Emanuele Mazzola

Research Scientist
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Dr.Mazzola’s main research focuses on different aspects of cancer biostatistics: within the general framework of risk prediction of invasive breast cancer following diagnoses of precancerous events, he has been mainly dealing with building expansions of the BRCAPRO model to account for diagnoses of: DCIS (Ductal Carcinoma in Situ) and Contralateral breast cancer.

Also, he is the PI of the recently awarded R03 grant “Risk assessment in atypical breast hyperplasia” aiming at the construction and validation of a new and comprehensive approach for risk assessment in women diagnosed with atypical hyperplasia of the breast (with G.Parmigiani, Ph.D, Su-Chun Cheng, Sc.D, Kevin Hughes, MD Ph.D).

On a more theoretical end, he is focusing on
Monte Carlo techniques for calibration of general microsimulation models
(with G.Parmigiani, Ph.D).

As a collaborative biostatistician, his other areas of interest are: Hematology (with D.Neuberg, Sc.D), Brain Cancer (with R.Segal, MD Ph.D), HIV (with R.Gelman, Ph.D).

He is also responsible of the preparation of educational material on clinical trials and reproducible research for in-person and online sessions to be conducted in conjunction with the Dana-Farber Cancer Institute’s Clinical Trials Education Office (with P.Catalano, Sc.D).



Dr.Mazzola received his M.S. in Mathematics from the Università degli Studi di Milano, Italy in 2002 with a thesis on spatial statistics. He then received a M.S. in Biostatistics from the Università degli Studi di Milano-Bicocca in 2005 with a thesis on Generalized linear models in ecotoxicology. In 2010 he received his Ph.D. in Statistics from the Università Commerciale L.Bocconi, Milano, Italy with a thesis on Lèvy processes. He has been a postdoctoral fellow under the mentorship of Prof. Giovanni Parmigiani from November 2010 at the Department of Biostatistics and Computational Biology at Dana-Farber Cancer Institute. He became a Research Associate in the same department in November 2012, and a Research Scientist in 2016.



Recent Publications


Cintolo-Gonzalez JA, Braun D, Blackford AL, Mazzola E, Acar A, Plichta JK, Griffin M, Hughes KS. Breast cancer risk models: a comprehensive overview of existing models, validation, and clinical applications. Breast Cancer Res Treat. 2017 Apr 25.



Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD. A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas. Neuro Oncol. 2017 Jun 1;19(6):774-785.



Turrero García M, Mazzola E, Harwell CC. Lineage Relationships Do Not Drive MGE/PoA-Derived Interneuron Clustering in the Brain. Neuron. 2016 Oct 5;92(1):52-58.



Bird GH, Mazzola E, Opoku-Nsiah K, Lammert MA, Godes M, Neuberg DS, Walensky LD. Biophysical determinants for cellular uptake of hydrocarbon-stapled peptide helices. Nat Chem Biol. 2016 Oct;12(10):845-52. 



Ojikutu BO, Mazzola E, Fullem A, Vega R, Landers S, Gelman RS, Bogart LM. HIV Testing Among Black and Hispanic Immigrants in the United States. AIDS Patient Care STDS. 2016 Jul;30(7):307-14.



Saade GR, Boggess KA, Sullivan SA, Markenson GR, Iams JD, Coonrod DV, Pereira LM, Esplin MS, Cousins LM, Lam GK, Hoffman MK, Severinsen RD, Pugmire T, Flick JS, Fox AC, Lueth AJ, Rust SR, Mazzola E, Hsu C, Dufford MT, Bradford CL, Ichetovkin IE, Fleischer TC, Polpitiya AD, Critchfield GC, Kearney PE, Boniface JJ, Hickok DE. Development and validation of a spontaneous preterm delivery predictor in asymptomatic women. Am J Obstet Gynecol. 2016 May;214(5):633.e1-633.e24.



Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA. A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp. 2015 Nov 7;(105):e53304.



Harwell CC, Fuentealba LC, Gonzalez-Cerrillo A, Parker PR, Gertz CC, Mazzola E, Garcia MT, Alvarez-Buylla A, Cepko CL, Kriegstein AR. Wide Dispersion and Diversity of Clonally Related Inhibitory Interneurons. Neuron. 2015 Sep 2;87(5):999-1007.



McEvoy MP, Coopey SB, Mazzola E, Buckley J, Belli A, Polubriaginof F, Merrill AL, Tang R, Garber JE, Smith BL, Gadd MA, Specht MC, Guidi AJ, Roche CA, Hughes KS. Breast Cancer Risk and Follow-up Recommendations for Young Women Diagnosed with Atypical Hyperplasia and Lobular Carcinoma In Situ (LCIS). Ann Surg Oncol. 2015 Oct;22(10):3346-9.



Gombos RB, Kolodkin-Gal D, Eslamizar L, Owuor JO, Mazzola E, Gonzalez AM, Korioth-Schmitz B, Gelman RS, Montefiori DC, Haynes BF, Schmitz JE. Inhibitory Effect of Individual or Combinations of Broadly Neutralizing Antibodies and Antiviral Reagents against Cell-Free and Cell-to-Cell HIV-1 Transmission. J Virol. 2015 Aug;89(15):7813-28.